‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold

‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2017, Volume: 27, Number: 6, Pages: 559-561 Pages count : 3 DOI: 10.1016/j.mencom.2017.11.006

Authors

Elinson Michail N. ¹ , Ryzhkov Fedor V. ¹ , Vereshchagin Anatoly N. ¹ , Korshunov Alexander D. ¹ , Novikov Roman A. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82–99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.

Elinson M.N. , Ryzhkov F.V. , Vereshchagin A.N. , Korshunov A.D. , Novikov R.A. , Egorov M.P.
‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold
Mendeleev Communications. 2017. V.27. N6. P.559-561. DOI: 10.1016/j.mencom.2017.11.006 WOS Scopus OpenAlex

Web of science:	WOS:000418983900006
Scopus:	2-s2.0-85035066146
OpenAlex:	W2768683583

DB	Citing
OpenAlex	21
Scopus	23
Web of science	21