Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes

Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes Full article

Journal

ChemMedChem
ISSN: 1860-7179 , E-ISSN: 1860-7187

Output data

Year: 2022, Volume: 17, Number: 20, Article number : e202200328, Pages count : DOI: 10.1002/cmdc.202200328

Authors

Coghi Paolo ¹ , Yaremenko Ivan A. ² , Prommana Parichat ³ , Wu Jia Ning ⁴ , Zhang Rui Long ⁴ , Ng Jerome P.L . ⁴ , Belyakova Yulia Yu. ² , Law Betty Yuen Kwan ⁴ , Radulov Peter S . ² , Uthaipibull Chairat ^3,5 , Wong Vincent K.W . ⁴ , Terent'ev Alexander O. ²

Affiliations

1	Macau University of Science and Technology, State Key Laboratory of Quality Research in Chinese Medicines, Avenida wai long, N/A, macau, MACAU.
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, 119991 Russia
3	National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Pathum Thani, 12120 Thailand
4	Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Avenida Wai Long, Taipa Macau P.R. China
5	Thailand Center of Excellence for Life Sciences (TCELS), Bangkok, Thailand

Bridged aminoperoxides exhibit good activity and selectivity toward the A549 lung cancer cell line. Bridged ozonides demonstrate high antimalarial activity in vitro and selectivity against the chloroquine-resistant P. falciparum strain K1. Ozonides induce apoptosis in HepG2 cells through a reactive oxygen species (ROS)-independent dysfunction pathway.

Coghi P. , Yaremenko I.A. , Prommana P. , Wu J.N. , Zhang R.L. , Ng J.P.L. , Belyakova Y.Y. , Law B.Y.K. , Radulov P.S. , Uthaipibull C. , Wong V.K.W. , Terent'ev A.O.
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes
ChemMedChem. 2022. V.17. N20. e202200328 . DOI: 10.1002/cmdc.202200328 WOS Scopus OpenAlex

Web of science:	WOS:000857951100001
Scopus:	2-s2.0-85138436799
OpenAlex:	W4294127577

DB	Citing
OpenAlex	16
Scopus	16
Web of science	13