Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold Научная публикация
| Журнал |
Polycyclic Aromatic Compounds
ISSN: 1563-5333 , E-ISSN: 1026-7743 |
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| Вых. Данные | Год: 2017, Том: 40, Номер: 1, Страницы: 108-115 Страниц : 8 DOI: 10.1080/10406638.2017.1363062 | ||
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Реферат:
The general multicomponent approach was found to the medicinally relevant 5-aryl-chromeno[2,3-b]pyridine scaffold. Triethylamine catalyzed multicomponent reaction of benzaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and dimedone in a minimal amount of propanol results in efficient formation of substituted 2,4-diamino-8,8-dimethyl-6-oxo-5-aryl-6,7,8,9-tetrahydro-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 75–80% yields. This general and efficient approach avoids traditional recrystallization and chromatographic purification stages and opens a convenient way to scaffolds, promising for many diverse oriented medical applications.
Библиографическая ссылка:
Elinson M.N.
, Vereshchagin A.N.
, Anisina Y.E.
, Egorov M.P.
Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold
Polycyclic Aromatic Compounds. 2017. V.40. N1. P.108-115. DOI: 10.1080/10406638.2017.1363062 WOS Scopus OpenAlex
Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold
Polycyclic Aromatic Compounds. 2017. V.40. N1. P.108-115. DOI: 10.1080/10406638.2017.1363062 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000510132200011 |
| Scopus: | 2-s2.0-85029430112 |
| OpenAlex: | W2754831135 |