Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold

Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold Full article

Journal

Polycyclic Aromatic Compounds
ISSN: 1563-5333 , E-ISSN: 1026-7743

Output data

Year: 2017, Volume: 40, Number: 1, Pages: 108-115 Pages count : 8 DOI: 10.1080/10406638.2017.1363062

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Anisina Yuliya E. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia

The general multicomponent approach was found to the medicinally relevant 5-aryl-chromeno[2,3-b]pyridine scaffold. Triethylamine catalyzed multicomponent reaction of benzaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and dimedone in a minimal amount of propanol results in efficient formation of substituted 2,4-diamino-8,8-dimethyl-6-oxo-5-aryl-6,7,8,9-tetrahydro-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 75–80% yields. This general and efficient approach avoids traditional recrystallization and chromatographic purification stages and opens a convenient way to scaffolds, promising for many diverse oriented medical applications.

Elinson M.N. , Vereshchagin A.N. , Anisina Y.E. , Egorov M.P.
Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold
Polycyclic Aromatic Compounds. 2017. V.40. N1. P.108-115. DOI: 10.1080/10406638.2017.1363062 WOS Scopus OpenAlex

Web of science:	WOS:000510132200011
Scopus:	2-s2.0-85029430112
OpenAlex:	W2754831135

DB	Citing
OpenAlex	18
Scopus	17