Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis

Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis Научная публикация

Журнал

Applied Biochemistry and Microbiology
ISSN: 1608-3024 , E-ISSN: 0003-6838

Вых. Данные

Год: 2019, Том: 55, Номер: 6, Страницы: 696-703 Страниц : 8 DOI: 10.1134/s0003683819060097

Авторы

Korolyova-Ushakova A.G. ¹ , Baranova E.V. ¹ , Ignatov S.G. ¹ , Soloviev P.V. ¹ , Kondakov N.N. ² , Mel’nikova T.M. ² , Abronina P.I. ² , Podval’nyi N.M. ² , Kononov L.O. ² , Biketov S.F. ¹

Организации

1	Science State Research Center for Applied Microbiology and Biotechnology, Federal Service for the Supervision of the Protection of Consumer Rights and Human Welfare, Moscow oblast, Obolensk, 142279 Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russia

Seven artificial mycobacterial antigens have been synthesized via the conjugation of synthetic carbohydrate epitopes of M. leprae phenolic glycolipid (PGL-1) and M. tuberculosis lipoarabinomannan (LAM) with bovine serum albumin (BSA). Each antigen has a different number of carbohydrate epitopes with a different structure and input sequence of the sugar residues. According to the serum reactivity, only three synthesized antigens can be useful for serodiagnosis of mycobacteriosis: (1) the antigen based on a disaccharide derivative of PGL-1: (DMG–Rha-AEP)-[BSA]; (2) the antigen based on a disaccharide fragment of PGL-1 and a hexasaccharide fragment of LAM: (DMG–Rha-AEP)-[BSA]–(Ara6-EG6); (3) the antigen based on the LAM diarabinofuranosyl fragment (Ara2-AEP)–[BSA].

Korolyova-Ushakova A.G. , Baranova E.V. , Ignatov S.G. , Soloviev P.V. , Kondakov N.N. , Mel’nikova T.M. , Abronina P.I. , Podval’nyi N.M. , Kononov L.O. , Biketov S.F.
Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis
Applied Biochemistry and Microbiology. 2019. V.55. N6. P.696-703. DOI: 10.1134/s0003683819060097 WOS Scopus OpenAlex

Web of science:	WOS:000501074300017
Scopus:	2-s2.0-85076292783
OpenAlex:	W2992789472

БД	Цитирований
OpenAlex	15
Scopus	14
Web of science	13