Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis Full article
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Applied Biochemistry and Microbiology
ISSN: 1608-3024 , E-ISSN: 0003-6838 |
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| Output data | Year: 2019, Volume: 55, Number: 6, Pages: 696-703 Pages count : 8 DOI: 10.1134/s0003683819060097 | ||||
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Abstract:
Seven artificial mycobacterial antigens have been synthesized via the conjugation of synthetic carbohydrate epitopes of M. leprae phenolic glycolipid (PGL-1) and M. tuberculosis lipoarabinomannan (LAM) with bovine serum albumin (BSA). Each antigen has a different number of carbohydrate epitopes with a different structure and input sequence of the sugar residues. According to the serum reactivity, only three synthesized antigens can be useful for serodiagnosis of mycobacteriosis: (1) the antigen based on a disaccharide derivative of PGL-1: (DMG–Rha-AEP)-[BSA]; (2) the antigen based on a disaccharide fragment of PGL-1 and a hexasaccharide fragment of LAM: (DMG–Rha-AEP)-[BSA]–(Ara6-EG6); (3) the antigen based on the LAM diarabinofuranosyl fragment (Ara2-AEP)–[BSA].
Cite:
Korolyova-Ushakova A.G.
, Baranova E.V.
, Ignatov S.G.
, Soloviev P.V.
, Kondakov N.N.
, Mel’nikova T.M.
, Abronina P.I.
, Podval’nyi N.M.
, Kononov L.O.
, Biketov S.F.
Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis
Applied Biochemistry and Microbiology. 2019. V.55. N6. P.696-703. DOI: 10.1134/s0003683819060097 WOS Scopus OpenAlex
Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis
Applied Biochemistry and Microbiology. 2019. V.55. N6. P.696-703. DOI: 10.1134/s0003683819060097 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000501074300017 |
| Scopus: | 2-s2.0-85076292783 |
| OpenAlex: | W2992789472 |