Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines

Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines Научная публикация

Журнал

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Вых. Данные

Год: 2017, Том: 53, Номер: 5, Страницы: 545-552 Страниц : 8 DOI: 10.1007/s10593-017-2091-z

Авторы

Gromachevskaya Elena V. ¹ , Kaigorodova Elena A. ² , Konyushkin Leonid D. ³

Организации

1	Kuban State Technological University, Krasnodar, Russia
2	Kuban State Agrarian University, Krasnodar, Russia
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

New 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines were obtained by a reaction of (2-aminophenyl)(diphenyl)carbinol with nitriles. Methylation of 3,4-dihydroquinazolines with excess of dimethyl sulfate occurred at two nitrogen atoms, while the subsequent alkaline hydrolysis was accompanied by opening of the heterocycle at the C(2)–N(3) bond, forming the respective amides. The molecular structure of N-methyl-N-{2-[(diphenyl)(methylamino)methyl]phenyl}benzamide was proved by X-ray structural analysis.

Gromachevskaya E.V. , Kaigorodova E.A. , Konyushkin L.D.
Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines
Chemistry of Heterocyclic Compounds. 2017. V.53. N5. P.545-552. DOI: 10.1007/s10593-017-2091-z WOS Scopus OpenAlex

≡ Web of science:	WOS:000404163000012
≡ Scopus:	2-s2.0-85020692176
≡ OpenAlex:	W2667453515