Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines

Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2017, Volume: 53, Number: 5, Pages: 545-552 Pages count : 8 DOI: 10.1007/s10593-017-2091-z

Authors

Gromachevskaya Elena V. ¹ , Kaigorodova Elena A. ² , Konyushkin Leonid D. ³

Affiliations

1	Kuban State Technological University, Krasnodar, Russia
2	Kuban State Agrarian University, Krasnodar, Russia
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

New 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines were obtained by a reaction of (2-aminophenyl)(diphenyl)carbinol with nitriles. Methylation of 3,4-dihydroquinazolines with excess of dimethyl sulfate occurred at two nitrogen atoms, while the subsequent alkaline hydrolysis was accompanied by opening of the heterocycle at the C(2)–N(3) bond, forming the respective amides. The molecular structure of N-methyl-N-{2-[(diphenyl)(methylamino)methyl]phenyl}benzamide was proved by X-ray structural analysis.

Gromachevskaya E.V. , Kaigorodova E.A. , Konyushkin L.D.
Studies on quinazoline chemistry 6*. Synthesis and alkylation of 2-substituted 4,4-diphenyl-3,4-dihydroquinazolines
Chemistry of Heterocyclic Compounds. 2017. V.53. N5. P.545-552. DOI: 10.1007/s10593-017-2091-z WOS Scopus OpenAlex

≡ Web of science:	WOS:000404163000012
≡ Scopus:	2-s2.0-85020692176
≡ OpenAlex:	W2667453515