Реферат: Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.

Библиографическая ссылка: Fershtat L.L. , Zhilin E.S.
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors
Molecules. 2021. V.26. N18. 5705 . DOI: 10.3390/molecules26185705 WOS Scopus OpenAlex

Идентификаторы БД:

Web of science:	WOS:000699822800001
Scopus:	2-s2.0-85115348416
OpenAlex:	W3199563840

Цитирование в БД:

БД	Цитирований
OpenAlex	43
Scopus	38
Web of science	36

Альметрики: