Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors Review
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Molecules
ISSN: 1420-3049 |
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| Output data | Year: 2021, Volume: 26, Number: 18, Article number : 5705, Pages count : DOI: 10.3390/molecules26185705 | ||
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Abstract:
Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.
Cite:
Fershtat L.L.
, Zhilin E.S.
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors
Molecules. 2021. V.26. N18. 5705 . DOI: 10.3390/molecules26185705 WOS Scopus OpenAlex
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors
Molecules. 2021. V.26. N18. 5705 . DOI: 10.3390/molecules26185705 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000699822800001 |
| Scopus: | 2-s2.0-85115348416 |
| OpenAlex: | W3199563840 |