Sciact
  • EN
  • RU

Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens Научная публикация

Журнал Russian Journal of Bioorganic Chemistry
ISSN: 1608-330X , E-ISSN: 1573-9163
Вых. Данные Год: 2018, Том: 44, Номер: 1, Страницы: 80-89 Страниц : 10 DOI: 10.1134/s1068162017060073
Авторы Krylov V.B. 1 , Petruk M.I. 1 , Grigoryev I.V. 2 , Lebedin Y.S. 2 , Glushko N.I. 3 , Khaldeeva E.V. 3 , Argunov D.A. 1 , Khatuntseva E.A. 1 , Toplishek M.V. 1 , Komarova B.S. 1 , Karelin A.A. 1 , Yudina O.N. 1 , Menshov V.M. 1 , Yashunskii D.V. 1 , Tsvetkov Y.E. 1 , Nifantiev N.E. 1
Организации
1 Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2 XEMA Company Limited, Moscow, Russia
3 Kazan Scientific Research Institute of Epidemiology and Microbiology, Kazan, Russia

Реферат: The carbohydrate specificity of antibodies obtained by immunizing laboratory animals with immunogens prepared from the Aspergillus fumigatus cell wall was analyzed using the library of biotinylated synthetic oligosaccharides. It has been shown that the main part of antipolysaccharide antibodies recognizes galactomannan in the studied immunogens with preference to its fragments containing more than two β-(1→5)-linked galactofuranosyl units. The data obtained can form the basis for the development of enzyme immunoassay for the detection of this dangerous fungal pathogen.
Библиографическая ссылка: Krylov V.B. , Petruk M.I. , Grigoryev I.V. , Lebedin Y.S. , Glushko N.I. , Khaldeeva E.V. , Argunov D.A. , Khatuntseva E.A. , Toplishek M.V. , Komarova B.S. , Karelin A.A. , Yudina O.N. , Menshov V.M. , Yashunskii D.V. , Tsvetkov Y.E. , Nifantiev N.E.
Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens
Russian Journal of Bioorganic Chemistry. 2018. V.44. N1. P.80-89. DOI: 10.1134/s1068162017060073 WOS Scopus OpenAlex
Идентификаторы БД:
≡ Web of science: WOS:000427499200008
≡ Scopus: 2-s2.0-85043981680
≡ OpenAlex: W2792112977
Альметрики: