A Novel Entry to 3,4,5-Trisubstituted 2-Pyrrolidones from Isoxazoline-N-oxides

A Novel Entry to 3,4,5-Trisubstituted 2-Pyrrolidones from Isoxazoline-N-oxides Full article

Journal

Synlett
ISSN: 0936-5214 , E-ISSN: 1437-2096

Output data

Year: 2018, Volume: 29, Number: 14, Pages: 1871-1874 Pages count : 4 DOI: 10.1055/s-0037-1610213

Authors

Zhmurov Petr A. ¹ , Ushakov Pavel Yu. ¹ , Novikov Roman A. ^1,2 , Sukhorukov Alexey Yu. ¹ , Ioffe Sema L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry
2	Department of Chemistry, M. V. Lomonosov Moscow State University

A novel strategy for the synthesis of stereochemically defined 3,4,5-trisubstituted 2-pyrrolidones was developed. The suggested approach involves reductive domino-type recyclization of 3-aminomethyl-substituted isoxazolines as a key stage. The latter are prepared via α-C–H functionalization of readily available isoxazoline-N-oxides.

Zhmurov P.A. , Ushakov P.Y. , Novikov R.A. , Sukhorukov A.Y. , Ioffe S.L.
A Novel Entry to 3,4,5-Trisubstituted 2-Pyrrolidones from Isoxazoline-N-oxides
Synlett. 2018. V.29. N14. P.1871-1874. DOI: 10.1055/s-0037-1610213 WOS Scopus OpenAlex

Web of science:	WOS:000442304600012
Scopus:	2-s2.0-85051941775
OpenAlex:	W2886953673

DB	Citing
OpenAlex	13
Scopus	12
Web of science	11