Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines Научная публикация
| Журнал |
Medicinal Chemistry Research
ISSN: 1554-8120 , E-ISSN: 1054-2523 |
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| Вых. Данные | Год: 2016, Том: 26, Номер: 1, Страницы: 170-179 Страниц : 10 DOI: 10.1007/s00044-016-1736-2 | ||||||
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Реферат:
Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.
Библиографическая ссылка:
Yaremenko I.A.
, Syroeshkin M.A.
, Levitsky D.O.
, Fleury F.
, Terent’ev A.O.
Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines
Medicinal Chemistry Research. 2016. V.26. N1. P.170-179. DOI: 10.1007/s00044-016-1736-2 WOS Scopus OpenAlex
Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines
Medicinal Chemistry Research. 2016. V.26. N1. P.170-179. DOI: 10.1007/s00044-016-1736-2 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000392064500016 |
| Scopus: | 2-s2.0-84994454876 |
| OpenAlex: | W2550864189 |