Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines

Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines Full article

Journal

Medicinal Chemistry Research
ISSN: 1554-8120 , E-ISSN: 1054-2523

Output data

Year: 2016, Volume: 26, Number: 1, Pages: 170-179 Pages count : 10 DOI: 10.1007/s00044-016-1736-2

Authors

Yaremenko Ivan A. ^1,2 , Syroeshkin Mikhail A. ¹ , Levitsky Dmitri O. ^2,3 , Fleury Fabrice ³ , Terent’ev Alexander O. ^2,1

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russian Federation
2	All-Russian Research Institute of Phytopathology, Bol’shie Vyazemy, Moscow region, 143050, Russian Federation
3	Mechanism and regulation of DNA repair team Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, Nantes, 44322, France

Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.

Yaremenko I.A. , Syroeshkin M.A. , Levitsky D.O. , Fleury F. , Terent’ev A.O.
Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines
Medicinal Chemistry Research. 2016. V.26. N1. P.170-179. DOI: 10.1007/s00044-016-1736-2 WOS Scopus OpenAlex

Web of science:	WOS:000392064500016
Scopus:	2-s2.0-84994454876
OpenAlex:	W2550864189

DB	Citing
OpenAlex	50
Scopus	46
Web of science	44