Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene

Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2021, Volume: 23, Number: 17, Pages: 6977-6981 Pages count : 5 DOI: 10.1021/acs.orglett.1c02603

Authors

Trifonov Alexey L ¹ , Dilman Alexander D ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation

A diversity-oriented and C2-selective synthesis of difluoroalkyl-substituted heteroarenes from three fragments, N-methoxyazinium salts, difluorocarbene, and electrophilic or radical reagents, is described. The reaction proceeds via the addition of difluorinated phosphorus ylide to in situ methylated heteroarene N-oxides, leading to phosphonium salts, which can undergo further transformations under basic or photoinduced conditions.

Trifonov A.L. , Dilman A.D.
Synthesis of Difluoroalkylated Heteroarenes via Difluorocarbene
Organic Letters. 2021. V.23. N17. P.6977-6981. DOI: 10.1021/acs.orglett.1c02603 WOS Scopus OpenAlex

Web of science:	WOS:000693633500073
Scopus:	2-s2.0-85114661296
OpenAlex:	W3195930966

DB	Citing
OpenAlex	26
Scopus	18
Web of science	22