Evidence for “cocktail”-type catalysis in Buchwald–Hartwig reaction. A mechanistic study

Evidence for “cocktail”-type catalysis in Buchwald–Hartwig reaction. A mechanistic study Full article

Journal

Catalysis Science & Technology
ISSN: 2044-4761 , E-ISSN: 2044-4753

Output data

Year: 2021, Volume: 11, Number: 21, Pages: 7171-7188 Pages count : 18 DOI: 10.1039/d1cy01601f

Authors

Prima Darya O. ¹ , Madiyeva Malena ^2,1 , Burykina Julia V. ¹ , Minyaev Mikhail E. ¹ , Boiko Daniil A. ^2,1 , Ananikov Valentine P. ^2,1

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospekt 47, Moscow, 119991, Russia
2	Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia

The mechanism of the C–N cross-coupling reaction, catalyzed by palladium complexes with N-heterocyclic carbene ligands (Pd/NHC), was evaluated in detail at the molecular and nanoscale levels. For the first time, the formation of a “cocktail”-type catalytic system was proven for the Buchwald–Hartwig reaction. The unique ability of the Pd/NHC system to generate several types of catalytic centers (Pd complexes, clusters and nanoparticles) and the involvement of complementary pathways (homogeneous and heterogeneous) were discovered to take place in a “one pot” manner directly in the reaction vessel. Access to various catalytic centers from a single and readily available Pd/NHC complex is the key to designing a universal catalytic system with adaptive tuning capability.

Prima D.O. , Madiyeva M. , Burykina J.V. , Minyaev M.E. , Boiko D.A. , Ananikov V.P.
Evidence for “cocktail”-type catalysis in Buchwald–Hartwig reaction. A mechanistic study
Catalysis Science & Technology. 2021. V.11. N21. P.7171-7188. DOI: 10.1039/d1cy01601f WOS Scopus OpenAlex

≡ Web of science:	WOS:000700914900001
≡ Scopus:	2-s2.0-85119011818
≡ OpenAlex:	W3204878281