Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests Научная публикация
| Журнал |
Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031 |
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| Вых. Данные | Год: 2014, Том: 48, Номер: 4, Страницы: 279-283 Страниц : 5 DOI: 10.1007/s11094-014-1094-7 | ||||
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Реферат:
Asynthesis of (13C-methoxy)methacetin, one of the most important agents for liver function diagnosis by stable-isotope breath tests, was developed. It was based on O-alkylation of phenols by alkylhalides through an intermediate potassium salt of paracetamol [N-(4-hydroxyphenyl)acetamide]. The synthesis was carried out using 13C-methyliodide in the presence of K2CO3 in one step under mild conditions (20 – 25°C) with high selectivity to isolate the product in 97.8% yield, 99.6 mass% purity, and 99.1 at% isotopic purity. The physical properties were determined. Physicochemical analytical methods for (13C-methoxy)methacetin using NMR and IR spectroscopy and ESI-MS mass spectrometry were developed and could be used for quality control of the product during preparation for its mass production.
Библиографическая ссылка:
El’man A.R.
, Davydov I.E.
, Kononov L.O.
, Zinin A.I.
, Dugin S.N.
Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests
Pharmaceutical Chemistry Journal. 2014. V.48. N4. P.279-283. DOI: 10.1007/s11094-014-1094-7 WOS Scopus OpenAlex
Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests
Pharmaceutical Chemistry Journal. 2014. V.48. N4. P.279-283. DOI: 10.1007/s11094-014-1094-7 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000340939700013 |
| Scopus: | 2-s2.0-84907368882 |
| OpenAlex: | W2070511542 |