Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests

Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2014, Volume: 48, Number: 4, Pages: 279-283 Pages count : 5 DOI: 10.1007/s11094-014-1094-7

Authors

El’man A.R. ¹ , Davydov I.E. ¹ , Kononov L.O. ² , Zinin A.I. ² , Dugin S.N. ¹

Affiliations

1	Rostkhim Ltd., Moscow, 111141, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia

Asynthesis of (13C-methoxy)methacetin, one of the most important agents for liver function diagnosis by stable-isotope breath tests, was developed. It was based on O-alkylation of phenols by alkylhalides through an intermediate potassium salt of paracetamol [N-(4-hydroxyphenyl)acetamide]. The synthesis was carried out using 13C-methyliodide in the presence of K2CO3 in one step under mild conditions (20 – 25°C) with high selectivity to isolate the product in 97.8% yield, 99.6 mass% purity, and 99.1 at% isotopic purity. The physical properties were determined. Physicochemical analytical methods for (13C-methoxy)methacetin using NMR and IR spectroscopy and ESI-MS mass spectrometry were developed and could be used for quality control of the product during preparation for its mass production.

El’man A.R. , Davydov I.E. , Kononov L.O. , Zinin A.I. , Dugin S.N.
Synthesis of (13C-Methoxy)Methacetin for Isotopic Breath Tests
Pharmaceutical Chemistry Journal. 2014. V.48. N4. P.279-283. DOI: 10.1007/s11094-014-1094-7 WOS Scopus OpenAlex

Web of science:	WOS:000340939700013
Scopus:	2-s2.0-84907368882
OpenAlex:	W2070511542

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OpenAlex	4
Web of science	3
Scopus	3