'Solvent-free’ and 'on-solvent’ multicomponent reaction of isatins, malononitrile, and bicyclic CH-acids: fast and efficient way to medicinal privileged spirooxindole scaffold

'Solvent-free’ and 'on-solvent’ multicomponent reaction of isatins, malononitrile, and bicyclic CH-acids: fast and efficient way to medicinal privileged spirooxindole scaffold Full article

Journal

Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004

Output data

Year: 2018, Volume: 2018, Number: 4, Pages: 276-285 Pages count : 10 DOI: 10.24820/ark.5550190.p010.640

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Ryzhkov Fedor V. ¹ , Anisina Yuliya E. ¹

Affiliations

1	Institute of Organic Chemistry, Leninsky prospect 47, 119 991 Moscow, Russia

The fast (15 min) PASE-'solvent-free' and 'on-solvent' multicomponent reactions of isatins, malononitrile and bicyclic CH-acids catalyzed by sodium acetate result in efficient formation of substituted spiro-oxindoles in 90– 98% yields. These methods are fast multicomponent approaches to the spiro-oxindoles, substances with promising anticancer activities. These new 'solvent-free' and 'on-solvent' techniques reduce solvent use, thereby leading to reduced waste, in connection with a new concept of solvent-assisted domino-reaction strategy.

Elinson M.N. , Vereshchagin A.N. , Ryzhkov F.V. , Anisina Y.E.
'Solvent-free’ and 'on-solvent’ multicomponent reaction of isatins, malononitrile, and bicyclic CH-acids: fast and efficient way to medicinal privileged spirooxindole scaffold
Arkivoc. 2018. V.2018. N4. P.276-285. DOI: 10.24820/ark.5550190.p010.640 Scopus OpenAlex

Scopus:	2-s2.0-85056868142
OpenAlex:	W2924404473

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