Trifluoromethyl-substituted 1,6-naphthyridines and pyrido[4,3-d]pyrimidines

Trifluoromethyl-substituted 1,6-naphthyridines and pyrido[4,3-d]pyrimidines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2013, Volume: 62, Number: 5, Pages: 1255-1261 Pages count : 7 DOI: 10.1007/s11172-013-0173-3

Authors

Vasil’ev L.S. ¹ , Surzhikov F.E. ¹ , Baranin S.V. ¹ , Dorokhov V.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A convenient method for the synthesis of 1-alkyl-5-trifluoromethyl-1,6-naphthyridin-4(1H)-ones was elaborated based on the reaction of 4-alkylamino-3-trifluoroacetimidoyl-3-penten-2-one diphenylboron chelates with dimethylformamide dimethyl acetal. 3-Acetyl-4-amino-2-trifluoromethylpyridine was used to obtain 5-trifluoromethyl-1,6-naphthyridin-4(1H)-one and its 2-methoxycarbonyl derivative, as well as 4-methyl-5-trifluoromethylpyrido-[4,3-d]pyrimidine.

Vasil’ev L.S. , Surzhikov F.E. , Baranin S.V. , Dorokhov V.A.
Trifluoromethyl-substituted 1,6-naphthyridines and pyrido[4,3-d]pyrimidines
Russian Chemical Bulletin. 2013. V.62. N5. P.1255-1261. DOI: 10.1007/s11172-013-0173-3 WOS Scopus OpenAlex

≡ Web of science:	WOS:000332793600018
≡ Scopus:	2-s2.0-84894643753
≡ OpenAlex:	W2010007729