Electrocatalytic multicomponent transformation of cyclic 1,3-diketones, isatins, and malononitrile: facile and convenient way to functionalized spirocyclic (5,6,7,8-tetrahydro-4H-chromene)-4,3′-oxindole system Full article
| Journal |
Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416 |
||
|---|---|---|---|
| Output data | Year: 2007, Volume: 63, Number: 42, Pages: 10543-10548 Pages count : 6 DOI: 10.1016/j.tet.2007.07.080 | ||
| Authors |
|
||
| Affiliations |
|
Abstract:
An electrochemically induced catalytic multicomponent transformation of cyclic 1,3-diketones, isatins, and malononitrile in alcohols in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized 5,6,7,8-tetrahydro-4H-chromene system in 83–98% yields. The application of this efficient electrocatalytic method to the formation of medicinally relevant spirocyclic (4H-chromene)-4,3′-oxindoles is beneficial from the viewpoint of diversity-oriented large-scale processes and represents novel, facile, and environmentally benign synthetic concept for multicomponent reaction strategy.
Cite:
Elinson M.N.
, Ilovaisky A.I.
, Dorofeev A.S.
, Merkulova V.M.
, Stepanov N.O.
, Miloserdov F.M.
, Ogibin Y.N.
, Nikishin G.I.
Electrocatalytic multicomponent transformation of cyclic 1,3-diketones, isatins, and malononitrile: facile and convenient way to functionalized spirocyclic (5,6,7,8-tetrahydro-4H-chromene)-4,3′-oxindole system
Tetrahedron. 2007. V.63. N42. P.10543-10548. DOI: 10.1016/j.tet.2007.07.080 WOS Scopus OpenAlex
Electrocatalytic multicomponent transformation of cyclic 1,3-diketones, isatins, and malononitrile: facile and convenient way to functionalized spirocyclic (5,6,7,8-tetrahydro-4H-chromene)-4,3′-oxindole system
Tetrahedron. 2007. V.63. N42. P.10543-10548. DOI: 10.1016/j.tet.2007.07.080 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000252092300017 |
| Scopus: | 2-s2.0-34548314643 |
| OpenAlex: | W2040962232 |