Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases

Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases Review

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1608-330X , E-ISSN: 1573-9163

Output data

Year: 2021, Volume: 47, Number: 1, Pages: 26-52 Pages count : 27 DOI: 10.1134/s1068162021010106

Authors

Khatuntseva E.A. ¹ , Nifantiev N.E. ¹

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia

This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysaccharide poly-3-β-D-ribosyl-(1→1)-D-ribitol-5-phosphate (PRP) or related synthetic oligosaccharide ligands. The methods for preparation of related oligosaccharide derivatives and results of the studies evaluating effect of their length on immunogenic properties of the conjugates with protein carriers are overviewed.

Khatuntseva E.A. , Nifantiev N.E.
Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
Russian Journal of Bioorganic Chemistry. 2021. V.47. N1. P.26-52. DOI: 10.1134/s1068162021010106 WOS Scopus OpenAlex

≡ Web of science:	WOS:000630869600002
≡ Scopus:	2-s2.0-85103353347
≡ OpenAlex:	W3137454875