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A carbon dioxide-promoted three-component Strecker reaction Научная публикация

Журнал Green Chemistry
ISSN: 1463-9262 , E-ISSN: 1463-9270
Вых. Данные Год: 2021, Том: 23, Номер: 24, Страницы: 10137-10144 Страниц : 8 DOI: 10.1039/d1gc03161a
Авторы Fauziev Ruslan V. 1 , Ivanov Roman E. 1 , Kuchurov Ilya 1 , Zlotin Sergei Grigorievich 1
Организации
1 I. N. Nazarov Laboratory of Fine Organic Synthesis, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991, Moscow, Russian Federation

Реферат: A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a ‘green’ solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications.
Библиографическая ссылка: Fauziev R.V. , Ivanov R.E. , Kuchurov I. , Zlotin S.G.
A carbon dioxide-promoted three-component Strecker reaction
Green Chemistry. 2021. V.23. N24. P.10137-10144. DOI: 10.1039/d1gc03161a WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:000723806300001
Scopus: 2-s2.0-85121553805
OpenAlex: W3215961757
Цитирование в БД:
БД Цитирований
OpenAlex 10
Scopus 10
Web of science 12
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