A carbon dioxide-promoted three-component Strecker reaction

A carbon dioxide-promoted three-component Strecker reaction Full article

Journal

Green Chemistry
ISSN: 1463-9262 , E-ISSN: 1463-9270

Output data

Year: 2021, Volume: 23, Number: 24, Pages: 10137-10144 Pages count : 8 DOI: 10.1039/d1gc03161a

Authors

Fauziev Ruslan V. ¹ , Ivanov Roman E. ¹ , Kuchurov Ilya ¹ , Zlotin Sergei Grigorievich ¹

Affiliations

1	I. N. Nazarov Laboratory of Fine Organic Synthesis, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991, Moscow, Russian Federation

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a ‘green’ solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications.

Fauziev R.V. , Ivanov R.E. , Kuchurov I. , Zlotin S.G.
A carbon dioxide-promoted three-component Strecker reaction
Green Chemistry. 2021. V.23. N24. P.10137-10144. DOI: 10.1039/d1gc03161a WOS Scopus OpenAlex

Web of science:	WOS:000723806300001
Scopus:	2-s2.0-85121553805
OpenAlex:	W3215961757

DB	Citing
OpenAlex	10
Scopus	10
Web of science	8