Fast highly efficient 'on-solvent' non catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes

Fast highly efficient 'on-solvent' non catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes Full article

Journal

Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004

Output data

Year: 2017, Volume: 2017, Number: 3, Pages: 121-129 Pages count : 9 DOI: 10.24820/ark.5550190.p010.023

Authors

Elinson Michail ¹ , Vereshchagin Anatoly N. ¹ , Sokolova Olga O. ¹

Affiliations

1	Department of Organic Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect 47, 119991 Moscow, Russia

Non-catalytic cascade reaction of benzaldehydes and two equivalents of 4-hydroxycoumarin initiated by reflux in propanol results in the fast (15 min) and efficient formation of substituted tetrahydro-1H-xanthen-1-ones in 93–98% yields. The developed fast cascade approach to the substituted bis(4- hydroxycoumarinyl)arylmethanes, which are known as medicinally relevant substances with anti-HIV, antibiotic, anti-inflammatory and anti-cancer activity, is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast, efficient and environmentally benign synthetic concept for cascade reactions strategy.

Elinson M. , Vereshchagin A.N. , Sokolova O.O.
Fast highly efficient 'on-solvent' non catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes
Arkivoc. 2017. V.2017. N3. P.121-129. DOI: 10.24820/ark.5550190.p010.023 Scopus OpenAlex

Scopus:	2-s2.0-85103074120
OpenAlex:	W2772778484

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