Synthesis of carbohydrate-amino acid conjugates related to the capsular antigen K54 from Escherichia coli O6:K54:H10 and artificial antigens therefrom Full article
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Carbohydrate Research
ISSN: 1873-426X , E-ISSN: 0008-6215 |
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| Output data | Year: 1992, Volume: 216, Pages: 381-398 Pages count : 18 DOI: 10.1016/0008-6215(92)84175-r | ||
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Abstract:
The disaccharides α-l-Rhap-(1 → 3)-β-d-GlcpA and β-·-GlcpA-(1 → 3)-α-l-Rhap bearing amide- linked l-serine or l-threonine, which represent the repeating unit(s) of the capsular polysaccharide from E. coli O6:K54:H10, have been synthesised. O-tert-Butyl-protected amino acid tert-butyl esters were condensed with the corresponding biouronic acid as the 2-acrylamidoethyl or 2-azidoethyl glycosides. The azido function was replaced by the acrylamido group by catalytic hydrogenation followed by N-acryloylation. The tert-butyl groups were removed by treatment with trifluoroacetic acid to give the target monomers which were copolymerised woth acrylamide to give neococonjugates that are potentially useful for immunochemical studies.
Cite:
Chernyak A.Y.
, Kononov L.O.
, Kochetkov N.K.
Synthesis of carbohydrate-amino acid conjugates related to the capsular antigen K54 from Escherichia coli O6:K54:H10 and artificial antigens therefrom
Carbohydrate Research. 1992. V.216. P.381-398. DOI: 10.1016/0008-6215(92)84175-r WOS Scopus OpenAlex
Synthesis of carbohydrate-amino acid conjugates related to the capsular antigen K54 from Escherichia coli O6:K54:H10 and artificial antigens therefrom
Carbohydrate Research. 1992. V.216. P.381-398. DOI: 10.1016/0008-6215(92)84175-r WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:A1991GH58600032 |
| Scopus: | 2-s2.0-0026414077 |
| OpenAlex: | W2043481907 |