Реферат: The polysaccharide capsule surrounding bacterial cell plays an important role in pathogenesis of infections caused by the opportunistic pathogen Acinetobacter baumannii by providing protection from external factors. The structures of the capsular polysaccharide (CPS) produced by A. baumannii isolates and the corresponding CPS biosynthesis gene clusters are highly diverse, although many of them are related. Many types of A. baumannii CPSs contain isomers of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acid (DTNA). Three of these isomers, namely acinetaminic acid (L-glycero-L-altro isomer), 8-epiacinetaminic acid (D-glycero-L-altro isomer), and 8-epipseudaminic acid (D-glycero-L-manno isomer), have not been found so far in naturally occurring carbohydrates from other species. In A. baumannii CPSs, DTNAs carry N-acyl substituents at positions 5 and 7; in some CPSs, both N-acetyl and N-(3-hydroxybutanoyl) groups are present. Remarkably, pseudaminic acid carries the (R)-isomer and legionaminic acid carries the (S)-isomer of the 3-hydroxybutanoyl group. The review addresses the structure and genetics of biosynthesis of A. baumannii CPSs containing di-N-acyl derivatives of DTNA.

Библиографическая ссылка: Knirel Y.A. , Kasimova A.A. , Arbatsky N.P. , Shneider M.M. , Popova A.V. , Brovko F.A. , Shashkov A.S. , Senchenkova S.N. , Perepelov A.V. , Shpirt A.M.
5,7-Diamino-3,5,7,9-tetradeoxynon-2-ulosonic Acids in the Capsular Polysaccharides of Acinetobacter baumannii
Biokhimiya. 2023. V.88. N2. P.202-210. DOI: 10.1134/s0006297923020049 WOS Scopus OpenAlex

Идентификаторы БД:

Web of science:	WOS:000948837000004
Scopus:	2-s2.0-85149953299
OpenAlex:	W4323838156

Цитирование в БД:

БД	Цитирований
OpenAlex	3
Scopus	3
Web of science	3

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